Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40173242.
- Also identified by DOI 10.1126/sciadv.ads5721 and PMC identifier 11964003.
- Licence recorded as CC BY-NC.
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Abstract
Human dipeptidyl peptidase 4 (hDPP-4) has been a pharmacological target for metabolic diseases, particularly diabetes, since the early 2000s. As a ubiquitous enzyme found in both prokaryotic and eukaryotic organisms, hDPP-4 plays crucial roles in host homeostasis and disease progression. While many studies have explored hDPP-4's properties, research on gut microbially derived DPP-4 (mDPP-4) remains limited. This review discusses the significance of mDPP-4 and its health implications, analyzing crystal structures of mDPP-4 in comparison to human counterparts. We examine how hDPP-4 inhibitors could influence gut microbiome composition and mDPP-4 activity. Additionally, this review connects ongoing discussions regarding DPP-4 substrate specificity and potential access routes for mDPP-4, emphasizing the urgent need for further research on mDPP-4's role in health and improve the precision of DPP-4 inhibitor therapies.
Medical subject headings
- Dipeptidyl Peptidase 4
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Host Microbial Interactions