Feeling the pressure: PIEZO2-positive sensory neurons regulate adipose function.
Where this comes from
- Record sourced from PubMed, PMID 40174573.
- Also identified by DOI 10.1016/j.cmet.2025.03.007.
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Abstract
Adipose tissue adapts to metabolic challenges through multiple regulatory mechanisms, including neuronal input. Although sympathetic neuronal regulation is well established, the impact of sensory feedback remains elusive. In this issue of Cell Metabolism, two studies reveal that sensory neurons expressing PIEZO2 modulate adipose function by inhibiting sympathetic output, reshaping our understanding of adipose surveillance and metabolism.
Medical subject headings
- Ion Channels
- Sensory Receptor Cells
- Adipose Tissue