Missing a trick? Bupropion for the pharmacological treatment of depression in the UK.

Browning, Michael; Cowen, Philip J · Br J Psychiatry · 2025

editorial · Level V

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Abstract

Bupropion is not licensed as an antidepressant in the UK, limiting its use. We highlight bupropion's distinct pharmacological profile and its potential benefits in treatment-resistant depression and people experiencing selective serotonin reuptake inhibitor-induced sexual dysfunction. The National Health Service repurposing medicines programme could improve equity of access for UK patients.

Medical subject headings