Centrifugal Spinning-Derived Biomimetic Aerogel for Rapid Hemostasis with Minimal Blood Loss.

Abstract

For emergency treatment, especially in situations where rapid and effective hemostasis is required beyond the natural clotting mechanisms, advanced materials designed to reduce bleeding time and minimize blood loss have become an urgent need. Herein, a root hair-inspired aerogel is developed, which is characterized by a 99.99% interconnected pore structure and a three-dimensional network constructed by blocked aqueous isocyanates cross-linked grooved cellulose acetate and wrinkled thermoplastic polyurethane fibers via centrifugal spinning. The aerogel exhibits enhanced water absorption and minimal blood adsorption through rapid coagulation cascade activation. <i>In vivo</i> studies using rat tail, hepatic, and renal injury models demonstrate a substantial reduction in blood loss (∼94%) and hemostasis time (∼78%) compared to commercial hemostats. The developed aerogel offers a promising solution for urgent hemorrhage control.