The clones have STRACK: Tracing responses to leukemic mutations.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40185067.
- Also identified by DOI 10.1016/j.stem.2025.03.001.
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Abstract
Rodriguez-Fraticelli and colleagues combine genetic barcoding with ex vivo expansion and sister-cell analysis of murine hematopoietic stem cells (HSCs) carrying inducible leukemia driver mutations. This approach allows them to capture the intrinsic heterogeneity of clonal cell behaviors and study how these impact cell fates upon acquisition of leukemia driver mutations.
Medical subject headings
- Mutation
- Leukemia
- Hematopoietic Stem Cells