A robust ingredient makes human gut stem cell niches on a dish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40185068.
- Also identified by DOI 10.1016/j.stem.2025.02.014.
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Abstract
Human intestinal organoids (HIOs) generated from induced pluripotent stem cells (iPSCs) are utilized for disease modeling but they lack a full complement of niche components. Childs et al.<sup>1</sup> demonstrate that EPIREGULIN-driven HIOs mature into functional, neuromuscular, and vascularized niches, establishing a powerful platform for human gut physiology and disease research.
Medical subject headings
- Stem Cell Niche
- Organoids
- Induced Pluripotent Stem Cells
- Intestines