A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40185071.
- Also identified by DOI 10.1016/j.stem.2025.03.003.
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Abstract
Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.
Medical subject headings
- Pluripotent Stem Cells
- Cell- and Tissue-Based Therapy
- Genetic Variation