Can a single brain cell be surprised?
basic_science · Level V
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- Record sourced from PubMed, PMID 40185709.
- Also identified by DOI 10.1038/s41467-025-57975-4 and PMC identifier 11971300.
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Abstract
A recent study by Buonomano et al. reports two important contributions; namely, empirical evidence for prediction error-like responses in single cells, using ex vivo preparations and optogenetics. Second, it foregrounds the role of asymmetric coupling in generating itinerant dynamics required for temporal prediction in neuronal circuits.