Myriad erythematous skin lesions, paresthesia, and anterior uveitis in a 34-year-old man.

Barton, Natasha; Mulvaney, Kathryn; Stein, Elizabeth; Baab, Kelsey; Henao-Martínez, Andrés; Wisell, Joshua; Newman, Sabrina · J Hosp Med · 2025

case_report · Level V

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Abstract

A 34-year-old man recently immigrated from Guam to Colorado presented with a 3-year history of skin lesions and months of worsening eye irritation and vision loss. Examination revealed leonine facies, tender erythematous nodules, corneal neovascularization, and granulomatous anterior uveitis. Diagnosed with multibacillary leprosy complicated by erythema nodosum leprosum, he responded well to multidrug therapy and immunosuppressive treatment, with significant improvement in systemic symptoms, ocular inflammation, and skin lesions at follow-up.

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