Active transport of cargo-carrying and interconnected chiral particles.

Abstract

Directed motion up a concentration gradient is crucial for the survival and maintenance of numerous biological systems, such as sperms moving towards an egg during fertilization or ciliates moving towards a food source. In these systems, chirality-manifested as a rotational torque-plays a vital role in facilitating directed motion. While systematic studies of active molecules in activity gradients exist, the effect of chirality remains little studied. In this study, we examine the simplest case of a chiral active particle connected to a passive particle in a spatially varying activity field. We demonstrate that this minimal setup can exhibit rich emergent tactic behaviors, with the chiral torque serving as the tuning parameter. Notably, when the chiral torque is sufficiently large, even a small passive particle enables the system to display the desired accumulation behavior. Our results further show that in the dilute limit, this desired accumulation behavior persists despite the presence of excluded volume effects. Additionally, interconnected chiral active particles exhibit emergent chemotaxis beyond a critical chain length, with trimers and longer chains exhibiting strong accumulation at sufficiently high chiral torques. This study provides valuable insights into the design principles of hybrid bio-molecular devices of the future.