Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40207621.
- Also identified by DOI 10.7554/eLife.98554 and PMC identifier 11984951.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is high, and there is currently no effective treatment available. This study aims to investigate the protective effects of exogenous mitochondrial transplantation in Sprague-Dawley (SD) rats. Exogenous mitochondrial transplantation can enhance myocardial function and improve the survival rate. Mechanistic studies suggest that mitochondrial transplantation can limit impairment in mitochondrial morphology, augment the activity of mitochondrial complexes II and IV, and raise ATP level. As well, mitochondrial therapy ameliorated oxidative stress imbalance, reduced myocardial injury, and thus improved PAMD after cardiopulmonary resuscitation (CPR).
Medical subject headings
- Heart Arrest
- Mitochondria
- Mitochondria, Heart