Association of Urinary Phthalate Metabolites With Pulmonary Function in Children: A Study Based on the NHANES.

Abstract

The aim of the study was to evaluate the links between single and combined urinary phthalate metabolites and respiratory function in children. We analyzed the data from National Health and Nutrition Examination Survey (2007-2012) with the final analysis encompassed 1644 participants, those divided into four groups on average. This study investigated the correlation between ten prevalent phthalate metabolites in pediatric urine samples and four pulmonary function indices, employing multivariable linear regression, segmented linear regression, and the weighted quantile sum methodologies for analysis. Significant negative correlations between eight phthalate metabolites. Additionally, the remaining seven phthalate metabolites showed significant negative associations with the predicted percentage of the ratio of forced expiratory volume in 1 second to forced vital capacity. The combined effects of various phthalate metabolites are the primary contributors to the decline in lung function.