Structural basis of ZP2-targeted female nonhormonal contraception.
basic_science · Level V
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- Record sourced from PubMed, PMID 40215272.
- Also identified by DOI 10.1073/pnas.2426057122 and PMC identifier 12012474.
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Abstract
Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an IE-3-derived single-chain variable fragment (scFV) is sufficient for blocking fertilization in vitro and determine the structural basis of IE-3/ZP2 recognition. The high affinity of this interaction depends on induced fit of the epitope, offering insights for nonhormonal contraceptive design without off-target effects.
Medical subject headings
- Zona Pellucida Glycoproteins
- Contraception
- Antibodies, Monoclonal