GLP-1-Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 40215332.
- Also identified by DOI 10.2337/db24-1071.
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Abstract
Weight loss defense mechanisms and inflammation challenge metabolic disease management, with few treatments available. We developed a mouse model of obesogenic memory and investigated the efficacy of a glucagon-like peptide 1/dexamethasone (GLP-1/Dexa) conjugate that safely and cell-selectively targets inflammation in GLP-1 receptor cells. GLP-1/Dexa offers a promising strategy to correct obesogenic memory and adipose tissue inflammation in male mice. CCR2 monocytes contribute to glucose intolerance associated with obesogenic memory and may be targeted by GLP-1/Dexa.
Medical subject headings
- Glucagon-Like Peptide 1
- Obesity
- Inflammation
- Dexamethasone