Entering the Era of Multidimensional Prognostication for Personalized Risk Assessment in Stage III Colon Cancer.

Rousseau, Benoit; Cercek, Andrea · J Clin Oncol · 2025

editorial · Level V

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Abstract

In the article that accompanies this editorial, Gallois et al. investigate the added value of transcriptomic signatures incorporating tumoral, stromal and immune features to refine the prognosis assessment of stage III colon cancer after resection. If prospectively validated, these findings pave the way for a personalized adjuvant strategy and possibly omission of adjuvant treatment for patients with very low risk disease or therapeutic intensification for high risk disease.