Jahn-Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection.

Abstract

Abundant ·OH, ¹O₂, and ·O₂^- provide an efficient methodology for rapid tumor and bacteria killing, whereas a limitation focuses on the catalytic efficiency. Thus, Jahn-Teller-driven electronic modulation of a bioheterojunction (bioHJ) platform is developed for the remedy in diabetic infectious wound regeneration after postoperative tumor resection. The bioHJ is composed of MoTe₂/MnO₂ and glucose oxidase (GOx). GOx depletes glucose to H₂O₂, which intercepts their glucose metabolism. The H₂O₂ can be further converted into highly lethal ·OH owing to peroxidase-mimetic activity via the Jahn-Teller effect, while GSH can be consumed due to its GPx-mimetic activity. Both of which can be further amplified upon NIR irradiation as NIR-activatable enzyme-mimetic activities. <i>In vivo</i> studies in a subcutaneous tumor model and infectious model authenticate the ability to kill tumor, defeat bacterial infection, and accelerate wound regeneration. This work enlightens a powerful platform for postoperative infectious wound regeneration of tumor resection using an engineered bioHJ.