Lipidome visualisation, comparison, and analysis in a vector space.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40233092.
- Also identified by DOI 10.1371/journal.pcbi.1012892 and PMC identifier 12058142.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A shallow neural network was used to embed lipid structures in a 2- or 3-dimensional space with the goal that structurally similar species have similar vectors. Tests on complete lipid databanks show that the method automatically produces distributions which follow conventional lipid classifications. The embedding is accompanied by the web-based software, Lipidome Projector. This displays user lipidomes as 2D or 3D scatterplots for quick exploratory analysis, quantitative comparison and interpretation at a structural level. Examples of published data sets were used for a qualitative comparison with literature interpretation.
Medical subject headings
- Lipidomics
- Lipids