Genomic language models could transform medicine but not yet.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40251342.
- Also identified by DOI 10.1038/s41746-025-01603-4 and PMC identifier 12008430.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recently, a genomic language model (gLM) with 40 billion parameters known as Evo2 has reached the same scale as the most powerful text large language models (LLMs). gLMs have been emerging as powerful tools to decode DNA sequences over the last five years. This article examines the emergence of gLMs and highlights Evo2 as a milestone in genomic language modeling, assessing both the scientific promise of gLMs and the practical challenges facing their implementation in medicine.