QBEmax is a sequence-permuted and internally protected base editor.
basic_science · Level V
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- Record sourced from PubMed, PMID 40258958.
- Also identified by DOI 10.1038/s41587-025-02641-9.
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Abstract
Cytosine base editors (CBEs) show promise for multiplex gene knockout applications, but impure edits, indels and off-targets still frequently occur. We describe here QBEmax, which exhibits high efficiency, low indel and off-targets and high product purity with up to 99.8% of edits comprised of C-to-T. Through molecular dynamic modeling, QBEmax presents as a compact and stable base editor that shields protected bases from undesired repair processes.