Application of Biomaterials for the Prevention of Pharyngeal Fistulae: A Systematic Review.
systematic_review · Level I
Where this comes from
- Record sourced from PubMed, PMID 40260473.
- Also identified by DOI 10.1002/hed.28175 and PMC identifier 12146823.
- Licence recorded as CC BY-NC-ND.
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Abstract
PharyngoCutaneous Fistulae (PCF) represent a significant clinical challenge in otorhinolaryngology practice. The use of biomaterials could improve outcomes or even replace the use of a flap in pharyngolaryngeal surgery. This systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery. A total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (n = 15) or to replace a mucosal defect and guide secondary healing (n = 4). Most studies evaluated commercialized biomaterials (n = 11) rather than experimental devices (n = 5) or platelet-derived autologous medical devices (n = 4). There are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.
Medical subject headings
- Biocompatible Materials
- Pharyngeal Diseases
- Cutaneous Fistula
- Postoperative Complications