Hepatic Venous Hemangioma Mimics Acetate-Positive Hepatocellular Carcinoma.

Zhao, Yiting; Chen, Cong; Zhang, Hong; Peng, Pan; Wang, Xuejuan · Clin Nucl Med · 2025

case_report · Level V

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Abstract

A 70-year-old man with prostate adenocarcinoma (Gleason score 4+3=7) and chronic hepatitis B underwent radical prostatectomy. A follow-up CT revealed a suspicious liver nodule in the left lobe nine months post-surgery. PSMA PET/CT scan revealed mild peripheral uptake in the liver lesion, atypical for metastatic prostate cancer. Further, 11 C-acetate PET/CT demonstrated significant uptake in the hepatic lesion, supporting a diagnosis of hepatocellular carcinoma. However, pathology after partial hepatectomy confirmed a hepatic venous hemangioma. This case highlights that benign hepatic vascular lesions can also exhibit PSMA and 11 C-acetate uptake, emphasizing careful differential diagnosis.

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