Financial Toxicity Across the Thyroid Cancer Care Continuum: A Systematic Review.

Abstract

To describe the financial toxicity (FT) associated with thyroid cancer (TC) across the care continuum and elucidate factors contributing to FT in this patient population. PubMed, Embase, Cochrane, Web of Science, and Scopus. A systematic review was conducted of peer-reviewed studies on FT in patients with a history of TC, between 1995 and 2024, using search terms "thyroid cancer," "financial toxicity," and their relevant synonyms. Full-text, English-language studies reporting subjective (self-reported FT) and objective (out-of-pocket [OOP], employment changes, and bankruptcy) FT outcomes were included. A total of 927 studies were identified, with 13 meeting the inclusion criteria. Nine studies addressed subjective FT, with prevalence rates ranging from 16% to 47%. Younger age, lack of health insurance, belonging to a racial minority, and having a lower annual household income were significantly associated with increased FT. Patients with TC had higher OOP costs and bankruptcy rates compared to other cancer types or matched controls. Despite a generally favorable prognosis, patients with TC experience significant FT, particularly among vulnerable groups such as younger individuals, the uninsured, and racial/ethnic minorities. In the setting of the rising incidence of TC, it is essential to identify and address FT in this population. Addressing FT requires a multifaceted approach, which includes incorporating financial counseling and cost discussions in routine care, ensuring comprehensive insurance coverage, and implementing employer-level protections to mitigate income and insurance loss. Further research is needed to understand the potential financial implications of different care pathways in the treatment of TC.