Immune Resilience: Rewriting the Rules of Healthy Aging.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40304045.
- Also identified by DOI 10.1111/acel.70089 and PMC identifier 12151910.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Aging is typically framed by disease, not resilience. This Perspective highlights immune resilience (IR) as a core determinant of healthy aging, based on new findings linking TCF7-driven immune profiles to extended healthspan and lifespan. IR buffers against immunosenescence, inflammaging, and senescent cell phenotypes, with benefits most pronounced before age 70. By reframing aging around salutogenesis rather than pathogenesis, this work shifts the focus toward resilience mechanisms and composite traits preserving health.
Medical subject headings
- Aging
- Healthy Aging
- Immunosenescence