Approaches to Imaging Immune Activation Using PET.

Parihar, Ashwin Singh; Pant, Niharika; Heidari, Pedram; Fong, Lawrence; Iravani, Amir · J Nucl Med · 2025

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Abstract

This review explores the role of PET in imaging immune activation, particularly in oncology. <sup>18</sup>F-FDG is widely used for assessing treatment response to immunotherapies and can demonstrate unique response patterns as well as immune-related adverse events. However, because of the limited specificity of <sup>18</sup>F-FDG, newer PET radiopharmaceuticals targeting specific cellular or subcellular components of the immune system have been developed that can provide more precise information. The development of immune-specific PET radiopharmaceuticals offers significant potential for improving immune monitoring in both clinical practice and research.

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