ALK-positive Histiocytosis Mimicking Colon Cancer on 18 F-FDG PET/CT.

Wang, Haijiang; Zhang, Wei; Zhang, Wenjie; Shen, Guohua · Clin Nucl Med · 2025

case_report · Level V

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Abstract

As a subtype of histiocytic neoplasm, ALK-positive histiocytosis is rare, especially with colorectal involvement. We herein describe 18 F-FDG PET/CT findings of ALK-positive histiocytosis with colon involvement in a 33-year-old man. The PET/CT scan demonstrated intense FDG uptake in the colonic lesion, along with multiple hypermetabolic lymph nodes. The colon cancer with lymph node metastases was initially suspected; however, the final pathological findings confirmed the diagnosis of ALK-positive histiocytosis.

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