Mutant macrophages CHIP in to help solid tumors.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40315816.
- Also identified by DOI 10.1016/j.cell.2025.03.049.
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Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) promotes adverse outcomes in age-related diseases. However, the impact of CHIP on solid tumors has yet to be elucidated in large-scale cancer-focused cohorts. In a recently published article in the New England Journal of Medicine, Pich et al. provide evidence for a tumor-promoting role of CHIP in solid malignancies.
Medical subject headings
- Neoplasms
- Macrophages
- Clonal Hematopoiesis