IRF6 hits the sweet spot.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40315828.
- Also identified by DOI 10.1016/j.stem.2025.04.002.
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Abstract
Glucose serves as an essential energy source for cells. In this issue, Lopez-Pajares et al.<sup>1</sup> uncover a role for glucose uncoupled from its energetic function. During epidermal differentiation, free glucose accumulates and binds the pro-differentiation transcription factor IRF6, promoting its dimerization and DNA binding to activate genes that drive differentiation.
Medical subject headings
- Interferon Regulatory Factors
- Glucose