Dopaminergic neurons entering the brain under the immunological cover of darkness.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40315830.
- Also identified by DOI 10.1016/j.stem.2025.04.004.
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Abstract
The ability to transplant immunologically foreign cells into an animal without immune suppression would be transformative. Pavan et al. show that human pluripotent stem cell-derived dopaminergic neuron progenitors engineered to express eight immune-evasive proteins can engraft in humanized mice and a rat model of Parkinson's disease without recourse to immune suppression.<sup>1</sup>.
Medical subject headings
- Dopaminergic Neurons
- Brain