Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40315831.
- Also identified by DOI 10.1016/j.stem.2025.03.015.
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Abstract
Yavitt et al.<sup>1</sup> introduce a photodegradable hydrogel platform to control crypt curvature in intestinal organoids, revealing how epithelial morphology directs Paneth cell localization. This innovative approach advances organoid engineering, providing a reproducible method to study stem cell niche interactions and model intestinal development and disease.
Medical subject headings
- Organoids
- Stem Cell Niche
- Intestines
- Tissue Engineering