Birth cohort and age-specific trends in global <i>Helicobacter pylori</i> seroprevalence: a scoping review.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40321652.
- Also identified by DOI 10.1016/j.lana.2024.100877 and PMC identifier 12049731.
- Licence recorded as CC BY-NC-ND.
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Abstract
Gastric cancer persists around the world as one of the leading causes of cancer-related death, despite declines in recent years. The declining prevalence of <i>H pylori</i>, the primary risk factor for gastric cancer, has contributed to this reduction and understanding changes in seroprevalence trends over time may yield further insight into gastric cancer incidence trends. We conducted a scoping review to compile data on <i>H pylori</i> seroprevalence in asymptomatic populations to assess global trends by age and birth cohort. We found that published data suggest <i>H pylori</i> seroprevalence declined among recent birth cohorts and increased with age, with trends differing between regions and sub-regions subject to data availability. The Americas lacked sufficient data to enable more robust assessment of <i>H pylori</i> trends by both age and birth cohort. NCI: U01CA265729, P30 CA008748; NIDDK: K08 DK125876.