Gout and NLRP3 Inflammasome Biology.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40322858.
- Also identified by DOI 10.1002/art.43215 and PMC identifier 12479186.
- Licence recorded as CC BY-NC-ND.
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Abstract
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self-resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal-induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome-mediated acute inflammation.
Medical subject headings
- Gout
- NLR Family, Pyrin Domain-Containing 3 Protein
- Inflammasomes