Treatable Traits as a Pathway to Remission in Asthma.

Abstract

In recent years, the significant impact of disease-modifying anti-asthmatic drugs has provided a chance to reevaluate goals in asthma treatment and consider remission as a more ambitious and achievable target. Clinical remission in asthma, both on- and off-treatment, has been characterized by the absence of asthma-related symptoms, attacks, and systemic corticosteroids, and the improvement or stabilization of lung function, all maintained over a minimum of 12 months. Targeting treatable traits has emerged as a promising strategy for the personalized treatment of chronic airway diseases in both primary and specialist care. This multidimensional approach involves the initial identification and tailored treatment of clinically essential characteristics in individual patients, called super-traits. Considering the heterogeneous and multifaceted nature of asthma and associated comorbidities, the novelty of this review is the proposal to use pulmonary, extrapulmonary, and behavioral treatable traits as a tool to reach remission.