Supramolecular Porous Materials for Biomedical Applications.

Abstract

Supramolecular porous materials have been used to tackle some major challenges in modern biomedical science, including disease therapy and diagnosis. Their inherent dynamicity, stimuli-responsiveness, and tunable architectures enable precise control over molecular recognition, cargo encapsulation, and release kinetics. This perspective explores their potential in diagnostics and therapeutics, highlighting adaptability to physiological stimuli and precise control over structure via bottom-up assembly. A visionary framework is proposed for programmable self-assembly, where supramolecular building blocks form porous architectures with customized channels and responsive behavior, facilitating applications in tissue engineering, biosensing, soft robotics, and cargo recognition. Addressing challenges related to building block design, assembly conditions, and scalability will be crucial for translating these materials from bench to bedside. This perspective underscores the transformative potential of supramolecular porous materials in advancing personalized medicine and smart diagnostics.