A Case of 99m Tc-Pyrophosphate Myocardial Scintigraphy Positivity in Fabry Disease.

Chen, Yang-Yun; Zhou, Yong-Rong; Jiang, Zhen-Peng; Wang, Shu-Xia; Shao, Dan · Clin Nucl Med · 2026

case_report · Level V

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Abstract

A 62-year-old man with echocardiographic findings suggestive of cardiac amyloidosis and positive 99m Tc-pyrophosphate ( 99m Tc-PYP) scintigraphy was ultimately diagnosed with Fabry disease confirmed by genetic testing. This case highlights myocardial 99m Tc-PYP uptake in Fabry cardiomyopathy, expanding the differential diagnosis of non-amyloid cardiomyopathies associated with myocardial radiotracer retention.

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