False-positive Uptake in Splenic Hamartoma on 68 Ga-DOTATATE PET/CT.

Wu, Chenxi; Foster, Julia W; Tajmir, Shahein; Shah, Hardik; Shah, Mihir M; Muzahir, Saima · Clin Nucl Med · 2026

case_report · Level V

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Abstract

68 Ga-DOTATATE is not completely specific for neuroendocrine tumors, and a wide range of benign and malignant tumors may reveal high uptake of 68 Ga-DOTATATE on PET scan. Spleen hamartoma is a rare benign solid lesion of the spleen, composed of a mixture of normal splenic structures. Here we present a case of a 49-year-old woman who underwent a 68Ga-DOTATATE PET/CT scan for complete staging of a duodenal neuroendocrine tumor, and it incidentally demonstrated intense radiotracer uptake in a splenic lesion, with surgical pathology demonstrating a splenic hamartoma.

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