Transfer of Herpes Simplex Virus Type 1 (HSV-1) Specific T Cells in a Pediatric Patient Post-HSCT With Severe, Acyclovir-resistant HSV-1 Infection.
case_report · Level V
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- Record sourced from PubMed, PMID 40364736.
- Also identified by DOI 10.1093/cid/ciaf125.
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Abstract
Herpes simplex virus (HSV) reactivation and acyclovir resistance are common complications in immunocompromised individuals. We report a pediatric hematopoietic stem cell transplantation (HSCT) recipient who received HSV-1-specific T cells from a partially human leukocyte antigen (HLA) matched donor for severe acyclovir-resistant HSV-1 mucositis resulting in clinical improvement, reduced plasma viral load, and emergence of antiviral T cells.