CXCR4-Targeted Imaging in Takayasu Arteritis Using 68 Ga-Pentixafor PET/CT.
case_report · Level V
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- Record sourced from PubMed, PMID 40367500.
- Also identified by DOI 10.1097/RLU.0000000000005975.
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Abstract
We report a case of a 64-year-old woman with Takayasu arteritis who underwent chemokine receptor CXCR4-targeted whole-body 68 Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) for further evaluation of disease activity and exclusion of concurrent inflammatory diseases. 68 Ga-Pentixafor PET demonstrated CXCR4-positive inflammatory cell infiltrates in the aortic wall, and active disease was further confirmed by 18 F-fluorodeoxyglucose (FDG) PET/CT. Moreover, 68 Ga-Pentixafor identified a CXCR4-positive pelvic bone lesion, and the patient was subsequently diagnosed with diffuse large B-cell lymphoma. CXCR4-targeted 68 Ga-Pentixafor PET is useful for the detection of active inflammation in Takayasu arteritis, and to detect neoplastic disease in this cohort with increased risk of malignancy.
Medical subject headings
- Takayasu Arteritis
- Positron Emission Tomography Computed Tomography
- Receptors, CXCR4
- Coordination Complexes
- Peptides, Cyclic