Radiation-induced amphiregulin drives tumour metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40369065.
- Also identified by DOI 10.1038/s41586-025-08994-0 and PMC identifier 13078179.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The anti-tumour effect of radiotherapy beyond the treatment field-the abscopal effect-has garnered much interest<sup>1</sup>. However, the potentially deleterious effect of radiation in promoting metastasis is less well studied. Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expressing myeloid cells toward an immunosuppressive phenotype and reduces phagocytosis. This stimulates distant metastasis growth in human patients and in pre-clinical mouse tumour models. The inhibition of these tumour-promoting factors induced by radiotherapy may represent a novel therapeutic strategy to improve patient outcomes.
Medical subject headings
- Amphiregulin
- Neoplasm Metastasis