Ythdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40371666.
- Also identified by DOI 10.1111/acel.70107 and PMC identifier 12266746.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Aging-related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m<sup>6</sup>A reader YTHDF2 is a negative regulator for dendrite development and protection of retinal ganglion cells (RGC) in mice. Here, we further show that conditional ablation of Ythdf2 protects the retina from RGC dendrite shrinking and vision loss in aged mice. Additionally, we identify Hspa12a and Islr2 as the potential YTHDF2 target mRNAs mediating these effects. Together, our results indicate that the m<sup>6</sup>A reader YTHDF2 regulates retinal degeneration caused by aging, which might provide important therapeutic potential for developing new treatment approaches against aging-related vision loss.
Medical subject headings
- Retinal Ganglion Cells
- Dendrites
- RNA-Binding Proteins
- Aging
- Retina
- Retinal Degeneration