Ultrafast and accurate sequence alignment and clustering of viral genomes.
Where this comes from
- Record sourced from PubMed, PMID 40374946.
- Also identified by DOI 10.1038/s41592-025-02701-7 and PMC identifier 12168504.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Viromics produces millions of viral genomes and fragments annually, overwhelming traditional sequence comparison methods. Here we introduce Vclust, an approach that determines average nucleotide identity by Lempel-Ziv parsing and clusters viral genomes with thresholds endorsed by authoritative viral genomics and taxonomy consortia. Vclust demonstrates superior accuracy and efficiency compared to existing tools, clustering millions of genomes in a few hours on a mid-range workstation.
Medical subject headings
- Genome, Viral
- Sequence Alignment
- Genomics
- Viruses