Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40378832.
- Also identified by DOI 10.1016/j.cell.2025.03.023.
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Abstract
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been overlooked and frequently persists. We discuss the privacy risks and research opportunities associated with mtDNA, urging consideration by the scientific, ethics, and legal communities.
Medical subject headings
- DNA, Mitochondrial
- Metagenome
- Metagenomics
- Genetic Privacy