A memory model of rodent spatial navigation in which place cells are memories arranged in a grid and grid cells are non-spatial.

Abstract

A theory and neurocomputational model are presented that explain grid cell responses as the byproduct of equally dissimilar hippocampal memories. On this account, place and grid cells are best understood as the natural consequence of memory encoding and retrieval; a precise hexagonal grid is the exception rather than the rule, emerging when the animal explores a large surface that is devoid of landmarks and objects. In the proposed memory model, place cells represent memories that are conjunctions of both spatial and non-spatial attributes, and grid cells primarily represent the non-spatial attributes (e.g. sounds, surface texture, etc.) found throughout the two-dimensional recording enclosure. Place cells support memories of the locations where non-spatial attributes can be found (e.g. positions with a particular sound), which are arranged in a hexagonal lattice owing to memory encoding and consolidation processes (pattern separation) as applied to situations in which the non-spatial attributes are found at all locations of a two-dimensional surface. Grid cells exhibit their spatial firing pattern owing to feedback from hippocampal place cells (i.e. a hexagonal pattern of remembered locations for the non-spatial attribute represented by a grid cell). Model simulations explain a wide variety of results in the rodent spatial navigation literature.