Atypical Presentation of Liver Metastasis in Medullary Thyroid Carcinoma: Variable Pattern and Interlesional Heterogeneity Observed on 18 F-FDG, 68 Ga-DOTATATE, and 68 Ga-DOTA-FAPI-04 PET/CT.
case_report · Level V
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- Record sourced from PubMed, PMID 40392188.
- Also identified by DOI 10.1097/RLU.0000000000005965.
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Abstract
Metastatic medullary thyroid carcinoma (MTC) can exhibit variable progression, with liver metastases occurring in up to 62% of cases. We report an unusual case of 50-year-old man with progressive MTC and atypical hypodense metastasis in the left lobe of liver that showed no tracer avidity on conventional 18 F-FDG and 68 Ga-DOTATATE PET/CT but was intensely avid on 68 Ga-DOTA-FAPI-04 PET/CT, implying a possible role of FAPI PET/CT imaging in diagnosing unusual metastatic lesions that may be missed on conventional PET imaging and also its theranostic potential for future management.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Thyroid Neoplasms
- Organometallic Compounds
- Liver Neoplasms
- Carcinoma, Neuroendocrine
- Fluorodeoxyglucose F18