Targeting STING antagonism in HSV-1: A peptide-based strategy to restore antiviral immunity and suppress viral pathogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40398394.
- Also identified by DOI 10.1016/j.xcrm.2025.102088 and PMC identifier 12147834.
- Licence recorded as CC BY-NC-ND.
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Abstract
Herpes simplex virus 1 (HSV-1) poses significant threats to human health. Wang et al.<sup>1</sup> show that the HSV-1 protein directly antagonizes stimulator of interferon genes (STING). A designed peptide derived from STING can restore virus-subverted immunity and inhibit HSV-1 replication and pathogenesis in mice.
Medical subject headings
- Herpesvirus 1, Human
- Membrane Proteins
- Peptides
- Herpes Simplex
- Antiviral Agents