2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Vilobelimab.

Nadig, Nandita; Bhimraj, Adarsh; Cawcutt, Kelly; Chiotos, Kathleen; Dzierba, Amy L; Kim, Arthur Y; Martin, Greg S; Pearson, Jeffrey C et al. · Clin Infect Dis · 2026

review · Level V

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Abstract

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019 (COVID-19), developed by the Infectious Diseases Society of America. The guideline panel presents a recommendation on the use of vilobelimab in hospitalized adults with critical COVID-19. The recommendation is based on evidence derived from a systematic literature review and adheres to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach.

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