In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40403116.
- Also identified by DOI 10.1161/CIRCRESAHA.125.325497 and PMC identifier 12180411.
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Abstract
Cardiovascular-kidney-metabolic syndrome is a progressive disorder driven by perturbed interorgan crosstalk among adipose, liver, kidney, and heart, leading to multiorgan dysfunction. Capturing the complexity of human cardiovascular-kidney-metabolic syndrome pathophysiology using conventional models has been challenging. Multi-organ-on-a-chip platforms offer a versatile means to study underlying interorgan signaling at different stages of cardiovascular-kidney-metabolic syndrome and bolster clinical translation.
Medical subject headings
- Metabolic Syndrome
- Lab-On-A-Chip Devices
- Kidney
- Cardiovascular Diseases
- Cardio-Renal Syndrome