Early-Phase Trials in <i>Journal of Clinical Oncology</i>.

Stinchcombe, Thomas E; Fleming, Gini F; Craddock, Charles; Ko, Andrew H; O'Reilly, Eileen M; Maki, Robert G · J Clin Oncol · 2025

editorial · Level V

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Abstract

In the article that accompanies this editorial, a well-designed trial confirmed that hearing can be protected through use of transtympanic thiosulfate injections in patients who receive high dose cisplatin with curative intent. In this editorial, members of the <i>Journal of Clinical Oncology</i> editorial board outline aspects of what constitutes high quality early phase trials with the goal of providing guidance for future JCO submissions.