Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability.

Shen, Dongchao; Zhang, Zhe; Guan, Hongzhi; You, Yan; Chang, Long; Cao, Xinxin · Neurology · 2025

case_report · Level V

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Abstract

We report a 59-year-old man with a progressively deteriorating neurologic presentation characterized by dysarthria and gait instability. Neurologic examination revealed pseudobulbar palsy, cerebellar ataxia, and pyramidal signs. Neuroimaging demonstrated irregular brainstem and cerebellar lesions with minimal mass effect and partial enhancement. Bilateral heel swelling, an uncommon clinical presentation, prompted further diagnostic evaluation. This case highlights the importance of a systematic reasoning approach, emphasizing the differential diagnosis, further investigative modalities, and treatment options for this rare condition, with particular attention to potential multisystem involvement.

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