Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40434228.
- Also identified by DOI 10.1002/adma.202418710 and PMC identifier 12354337.
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Abstract
Laser particles (LPs) emitting narrowband spectra across wide spectral ranges are highly promising for high-multiplex optical barcoding of biological cells. Here, LPs based on indium phosphide (InP) nanodisks are presented, operating in the near-infrared wavelength range of 740-970 nm. Utilizing low-order whispering gallery resonance modes in size-tuned nanodisks, an ultrawide color palette with 25% spectral utilization and nanometer-scale linewidth is achieved. A simple theoretical model accurately predicts spectral ranges based on particle size. The minimum laser size is 430 nm in air and 560 nm within cells, operating at mode orders of 4 or 5. The high brightness and narrow linewidths of polymer-silica-protected InP LPs, combined with a silicon-detector spectrometer, enable spectral detection of laser peaks with high signal-to-background ratios in highly-scattering media, including 1-cm-thick chicken breast tissue and blood vessels in live mice.
Medical subject headings
- Indium
- Phosphines
- Lasers
- Nanoparticles