Progress in the application of organoids for exploring the relationship between macrophages and various lung diseases.
review · Level V
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- Record sourced from PubMed, PMID 40436032.
- Also identified by DOI 10.1088/1758-5090/adde15.
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Abstract
Organoids cultured<i>ex vivo</i>mimic<i>in vivo</i>tissue and organ characteristics. They have become a focus in research for their potential in modeling macrophage function in respiratory diseases, offering insights into disease mechanisms and therapeutic strategies. A number of studies have confirmed organoids' utility in dissecting microbial interactions, disease modeling, genetic manipulation, and high-throughput drug screening for efficacy and safety. This review summarizes the research progress on organoids in exploring macrophage involvement in pulmonary diseases.
Medical subject headings
- Organoids
- Lung Diseases
- Macrophages